| Name | Region | Compatibility | User Rating |
|---|---|---|---|
| Carol Vorderman's Sudoku | Region USA 1.01 | Compat Unreported | Rating |
| CARROS | Region Europe 1.01 | Compat Unreported | Rating |
| CARS | Region Hong Kong 1.00 | Compat Unreported | Rating |
| CARS | Region Europe 1.00 | Compat Unreported | Rating |
| CARS | Region Europe 1.01 | Compat Unreported | Rating |
| CART KINGS | Region Europe 1.01 | Compat Unreported | Rating |
| Castle Rustle | Region Europe 1.02 | Compat Unreported | Rating |
| Castlevania 1 | Region Homebrew 1.00 | Compat Unreported | Rating |
| Castlevania III - Dracula's Curse - Nes | Region Homebrew 1.00 | Compat Unreported | Rating |
| Castlevania Rondo of Blood | Region Europe 1.02 | Compat Unreported | Rating |
| Caterpillar | Region Europe 1.01 | Compat Unreported | Rating |
| Caterpillar | Region USA 1.02 | Compat Unreported | Rating |
| chameleon | Region USA 1.01 | Compat Unreported | Rating |
| Championship Manager | Region Europe 1.02 | Compat Unreported | Rating |
| Championship Manager | Region Europe 1.00 | Compat Unreported | Rating |
| Championship Manager | Region Europe 1.00 | Compat Unreported | Rating |
| Championship Manager | Region Europe 1.00 | Compat Unreported | Rating |
| Championship Manager 2010 | Region Europe 1.01 | Compat Unreported | Rating |
| Chandragupta | Region Europe 1.01 | Compat Unreported | Rating |
| CHAOS;HEAD NOAH | Region Japan 1.01 | Compat Unreported | Rating |
| Charge! Tank Squad! | Region USA 1.00 | Compat Unreported | Rating |
| Cherry blossom Portable | Region Japan 1.01 | Compat Unreported | Rating |
| Chessmaster: The Art of Learning | Region Europe 1.00 | Compat Unreported | Rating |
| Chi Vuol Essere Milionario - Party Edition | Region Europe 1.01 | Compat Unreported | Rating |
| Cho Aniki Zero | Region USA 1.00 | Compat Unreported | Rating |
| CID The Dummy | Region Europe 1.01 | Compat Unreported | Rating |
| Circles | Region USA 1.00 | Compat Unreported | Rating |
| CIRCLES, CIRCLES, CIRCLES | Region Europe 1.01 | Compat Unreported | Rating |
| CLADUN: This is an RPG! | Region Europe 1.02 | Compat Unreported | Rating |
| CLADUN™: This is an RPG! | Region USA 2.00 | Compat Unreported | Rating |
| Class of Heroes 2 | Region USA 1.02 | Compat Unreported | Rating |
| Class of Heroes 2 | Region USA 2.00 | Compat Unreported | Rating |
| Class of Heroes 2 | Region USA 1.01 | Compat Unreported | Rating |
| CLOCK ZERO ～終焉の一秒～ Portable | Region Japan 1.02 | Compat Unreported | Rating |
| Coconut Dodge | Region Europe 2.01 | Compat Unreported | Rating |
| Coconut Dodge | Region USA 1.02 | Compat Unreported | Rating |
| Code Name: Viper | Region Homebrew | Compat Unreported | Rating |
| Coded Arms® Contagion | Region Japan 1.02 | Compat Unreported | Rating |
| Coded Gun® Contagion | Region Hong Kong 1.02 | Compat Unreported | Rating |
| Coded Soul | Region Japan 1.00 | Compat Unreported | Rating |
| Coded Soul | Region Hong Kong 1.00 | Compat Unreported | Rating |
| code_18 | Region Japan 1.02 | Compat Unreported | Rating |
| Colin McRae™ DiRT® 2™ | Region Japan 1.01 | Compat Unreported | Rating |
| CONCEPTION 俺の子供を産んでくれ！ 体験版 | Region Japan 1.00 | Compat Unreported | Rating |
| Confidential Money ～300日で3000万ドル稼ぐ方法～ | Region Japan 1.02 | Compat Unreported | Rating |
| contra 1 | Region Homebrew 1.00 | Compat Unreported | Rating |
| Contra: The Hard corps - Sega Genesis | Region Homebrew 1.00 | Compat Unreported | Rating |
| CORE BLASTER | Region Europe 1.01 | Compat Unreported | Rating |
| CORPSE PARTY | Region Europe 1.00 | Compat Unreported | Rating |
| Corpse Party: Book of Shadows | Region Europe 1.01 | Compat Unreported | Rating |
| Cover Girl | Region Europe 1.00 | Compat Unreported | Rating |
| Crash Team Racing | Region Homebrew 1.00 | Compat Unreported | Rating |
| Crazy Taxi: Fare Wars | Region Europe 0.01 | Compat Unreported | Rating |
| CREATURE DEFENSE | Region USA 1.00 | Compat Unreported | Rating |
| CRIMSON ROOM Reverse | Region USA 1.01 | Compat Unreported | Rating |
| Crystal Defenders | Region Europe 01.00 | Compat Unreported | Rating |
| CRYSTAL DEFENDERS | Region USA 01.00 | Compat Unreported | Rating |
| Crystal Mines | Region Europe 1.03 | Compat Unreported | Rating |
| CUBE™ | Region Europe 1.01 | Compat Unreported | Rating |
| Cubixx | Region USA 1.01 | Compat Unreported | Rating |
| CUSTOM DRIVE | Region Japan 1.03 | Compat Unreported | Rating |
| D-CUBE PLANET | Region Europe 1.02 | Compat Unreported | Rating |
| D.C.P.S. | Region Japan 1.03 | Compat Unreported | Rating |
| Daedalus64 | Region USA 01.00 | Compat Unreported | Rating |
| DANGANRONPA | Region Japan 1.01 | Compat Unreported | Rating |
| Dante's Inferno™ | Region Japan 1.02 | Compat Unreported | Rating |
| DAXTER | Region USA 1.01 | Compat Unreported | Rating |
| Daxter™ | Region Europe 1.00 | Compat Unreported | Rating |
| DAYS OF THUNDER psp2home.ru | Region USA 1.01 | Compat Unreported | Rating |
| DEAD OR ALIVE Paradise | Region Europe 1.02 | Compat Unreported | Rating |
| DEARDROPS DISTORTION | Region Japan 1.03 | Compat Unreported | Rating |
| Death, Jr. | Region Europe 1.03 | Compat Unreported | Rating |
| Def Jam® Fight For NY™: The Takeover | Region Asia 1.00 | Compat Unreported | Rating |
| Def Jam® Fight For NY™: The Takeover | Region Hong Kong 1.00 | Compat Unreported | Rating |
| Defenders of the Mystic Garden | Region USA 1.01 | Compat Unreported | Rating |
| Demo | Region Homebrew 1.00 | Compat Unreported | Rating |
| Demo Disc for PSP™ vol. 2 | Region Europe 1.01 | Compat Unreported | Rating |
| Denki Blocks! | Region Europe 1.00 | Compat Unreported | Rating |
| Der Goldene Kompass™ | Region Europe 1.00 | Compat Unreported | Rating |
| Der Herr der Ringe: Taktiken™ | Region Europe 1.00 | Compat Unreported | Rating |
| Der Pate® | Region Europe 1.00 | Compat Unreported | Rating |
| Dies irae ?Amantes amentes? DISC2 | Region Japan 1.02 | Compat Unreported | Rating |
| Dies irae ～Amantes amentes～ DISC1 | Region Japan 1.02 | Compat Unreported | Rating |
| DIGI-TILES™ | Region USA 1.00 | Compat Unreported | Rating |
| DISGAEA Afternoon of Darkness | Region Europe 1.00 | Compat Unreported | Rating |
| Disgaea Infinite | Region USA 1.00 | Compat Unreported | Rating |
| Disney•Pixar UP | Region Europe 1.01 | Compat Unreported | Rating |
| Disney•Pixar UP | Region Europe 1.00 | Compat Unreported | Rating |
| Disney•Pixar UP | Region Europe 1.00 | Compat Unreported | Rating |
| DISSIDIA duodecim prologus FINAL FANTASY | Region Southeast Asia 1.00 | Compat Unreported | Rating |
| DISSIDIA duodecim prologus FINAL FANTASY | Region Japan 1.00 | Compat Unreported | Rating |
| DISSIDIA FINAL FANTASY | Region Europe 1.00 | Compat Unreported | Rating |
| DISSIDIA FINAL FANTASY UNIVERSAL TUNING | Region Japan 1.00 | Compat Unreported | Rating |
| DJMAX PORTABLE 3 Demo | Region Southeast Asia 1.01 | Compat Unreported | Rating |
| DON 2 - THE GAME | Region Europe 1.00 | Compat Unreported | Rating |
| Dongfang Queshen™ | Region Southeast Asia 1.00 | Compat Unreported | Rating |
| Donkey Kong 1 - Nes | Region Homebrew 1.0 | Compat Unreported | Rating |
| Donkey Xote™ | Region Europe 1.02 | Compat Unreported | Rating |
| Doodle Fit | Region Europe 1.00 | Compat Unreported | Rating |
| Doodle Fit | Region USA 1.00 | Compat Unreported | Rating |