| Name | Region | Compatibility | User Rating |
|---|---|---|---|
| Shapo | Region Europe 1.01 | Compat Unreported | Rating |
| Shapo | Region USA 1.00 | Compat Unreported | Rating |
| Sheep Defense | Region USA 1.00 | Compat Unreported | Rating |
| SMASHBREAK™ | Region USA 1.00 | Compat Unreported | Rating |
| Snake Warriors: Training | Region USA 1.01 | Compat Unreported | Rating |
| SNOWY: THE BEAR'S ADVENTURES | Region USA 1.01 | Compat Unreported | Rating |
| Soccer Bashi | Region Europe 1.02 | Compat Unreported | Rating |
| Solitaire | Region USA 1.00 | Compat Unreported | Rating |
| SPACEBALL: REVOLUTION | Region Europe 1.01 | Compat Unreported | Rating |
| SPACEBALL: REVOLUTION | Region USA 1.00 | Compat Unreported | Rating |
| Speedball 2 Evolution | Region Europe 1.01 | Compat Unreported | Rating |
| Star Hammer Tactics | Region USA 1.00 | Compat Unreported | Rating |
| STELLAR ATTACK | Region USA 1.01 | Compat Unreported | Rating |
| Stick Man Rescue | Region Europe 1.01 | Compat Unreported | Rating |
| SUDOKU | Region USA 1.00 | Compat Unreported | Rating |
| Super Fruitfall Deluxe | Region Europe 1.02 | Compat Unreported | Rating |
| Swap Zap | Region Europe 1.03 | Compat Unreported | Rating |
| Sweet Reversi | Region USA 1.00 | Compat Unreported | Rating |
| Telegraph Crosswords | Region Europe 1.02 | Compat Unreported | Rating |
| Tetraminos | Region Europe 1.04 | Compat Unreported | Rating |
| The Marbians | Region Europe 1.03 | Compat Unreported | Rating |
| The Mystery of the Crystal Portal | Region Europe 1.00 | Compat Unreported | Rating |
| The Terminator | Region Europe 1.02 | Compat Unreported | Rating |
| This is Football Management™ | Region Europe 2.01 | Compat Unreported | Rating |
| This Is Football Managment | Region Europe 1.00 | Compat Unreported | Rating |
| TIGER TROUBLE | Region Europe 1.00 | Compat Unreported | Rating |
| Tiny Hawk | Region Europe 1.00 | Compat Unreported | Rating |
| Tonzurakko | Region USA 1.00 | Compat Unreported | Rating |
| TOP GUN | Region USA 1.01 | Compat Unreported | Rating |
| Twin Blades | Region USA 1.01 | Compat Unreported | Rating |
| Vempire | Region Europe 1.03 | Compat Unreported | Rating |
| Vibes | Region USA 1.02 | Compat Unreported | Rating |
| Vibes | Region USA 2.01 | Compat Unreported | Rating |
| WackyLands: Boss | Region Europe 1.01 | Compat Unreported | Rating |
| Where is my Heart? | Region Europe 1.02 | Compat Unreported | Rating |
| Widget's Odyssey | Region Europe 1.02 | Compat Unreported | Rating |
| Widgets Odyssey 2 | Region Europe 1.00 | Compat Unreported | Rating |
| Wizorb | Region Europe 1.02 | Compat Unreported | Rating |
| Wizorb | Region USA 1.02 | Compat Unreported | Rating |
| YOUNG THOR | Region Japan 1.01 | Compat Unreported | Rating |
| YUMMY YUMMY COOKING JAM | Region Europe 1.01 | Compat Unreported | Rating |
| Zombie Racers | Region Europe 1.01 | Compat Unreported | Rating |
| ZOMBIE TYCOON | Region USA 1.00 | Compat Unreported | Rating |
| とんずらっこ™ | Region Japan 1.00 | Compat Unreported | Rating |
| バトルピンボール | Region Japan 1.00 | Compat Unreported | Rating |
| メイクドラマベースボール™ | Region Japan 1.00 | Compat Unreported | Rating |